Questão 2371387

Text for the items from 17 to 22.

1 Postmortem findings from Scotland have

emphatically addressed ischemic brain damage in

non-missile severe acute brain trauma. Such findings from

4 dead brains, however, were documented under

circumstances that do not reproduce physiological

parameters in alive brains, such as during intensive care.

7 Indeed, as a general rule in neurotrauma acute

care, prolonged periods of hours or even days will have

elapsed between the moment when clinical signs of brain

10 death are first documented and the time when supportive

measures are finally discontinued. Accordingly, the brains

evaluated by neuropathologists will have almost invariably

13 sustained ultra-prolonged periods of very low or even

absent cerebral perfusion, because of very high intracranial

pressure (ICP), low blood pressure, or a combination of

16 both; that is, cerebral perfusion pressure (CPP) will have

approached zero for prolonged periods.

Accordingly, it is not surprising that postmorte

19 studies in severe acute brain trauma may frequently

disclose ischemic damage. In alive brains, however,

adequate ICP and blood pressure levels are frequently

22 found during intensive care and, therefore, factors other

than CPP are expected to play a relevant role, insofar as

cerebral hemodynamics and metabolism are concerned.

25 From the above discussion, extrapolation from cadaver

brains to alive patients during most of the acute phase of

injury is largely inappropriate.

_{Internet: <www.scielo.br> (adapted).}

Based on the text, judge the following items.

“therefore” (line 22) could be correctly replaced by thus.