Questão 2757669

Carbonic anhydrase inhibitors such as acetazolamide increase the elimination of bicarbonate accompanied by Na+, K+, and water, resulting in increased flow of alkaline urine and metabolic acidosis.

Thiazide diuretics increase the elimination of calcium, therefore being not very advantageous for use in older patients at risk of osteoporosis.

Triamterene and amiloride have only limited efficacy as diuretics because they act on the proximal nephron, where only a small fraction of Na reabsorption occurs.

Loop diuretics reach their site of action, the luminal membrane of the cells of the thick ascending limb, as they are secreted in the proximal convoluted tubule by the organic acid transport mechanism.